Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ppargtm1Tka
Name:	peroxisome proliferator activated receptor gamma; targeted mutation 1, Takashi Kadowaki
MGI ID:	MGI:2429766
Synonyms:	PPARgamma-
Gene:	Pparg  Location: Chr6:115337912-115467360 bp, + strand  Genetic Position: Chr6, 53.41 cM, cytoband E3-F1
Alliance:	Ppargtm1Tka page

Germline Transmission:	Earliest citation of germline transmission: J:58222
Parent Cell Line:	TT2 (ES Cell)
Strain of Origin:	(C57BL/6NCrlj x CBA/JNCrlj)F1

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A neomycin selection cassette was inserted in exon 1 immediately upstream of the endogenous start codon. Northern blot analysis of homozygous mutant mice indicated an absence of transcript. (J:58222)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

7 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pparg Mutation:	39 strains or lines available

Original:	J:58222 Kubota N, et al., PPAR gamma mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance. Mol Cell. 1999 Oct;4(4):597-609
All:	12 reference(s)