Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Il6sttm1Ern
Name:	interleukin 6 signal transducer; targeted mutation 1, Matthias Ernst
MGI ID:	MGI:2388478
Synonyms:	gp130757F, gp130F, gp130Y757F, gp130Y757F
Gene:	Il6st  Location: Chr13:112600604-112643394 bp, + strand  Genetic Position: Chr13, 63.73 cM
Alliance:	Il6sttm1Ern page

Germline Transmission:	Earliest citation of germline transmission: J:79073
Parent Cell Line:	W9.5/W95 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Nucleotide substitutions   Mutation details: The Ptpn11 binding domain, encoded by sequence in exon 17, was disrupted by homologous recombination of a construct containing missense mutations at codons 757 (tyrosine to phenylalanine) and 760 (valine to alanine). Furthermore, an IRES-neo cassette was inserted into the 3' region of exon 17. A biochemical assay of liver tissue showed that the Il6st mediated signalling pathway was disrupted in mutant mice. (J:79073)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	9 anatomical structure(s)

List all tumor models in MMHCdb carrying Il6sttm1Ern

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 13 strains available      Cell Lines: 0 lines available
Carrying any Il6st Mutation:	80 strains or lines available

Original:	J:79073 Tebbutt NC, et al., Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice. Nat Med. 2002 Oct;8(10):1089-97
All:	62 reference(s)