Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Drd3tm1Schm
Name:	dopamine receptor D3; targeted mutation 1, Claudia Schmauss
MGI ID:	MGI:2388387
Synonyms:	D3 -
Gene:	Drd3  Location: Chr16:43574389-43643295 bp, + strand  Genetic Position: Chr16, 28.44 cM
Alliance:	Drd3tm1Schm page

Germline Transmission:	Earliest citation of germline transmission: J:79483
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 3 was disrupted by the insertion of a neomycin selection cassette. While normal transcript was undetected by RT-PCR analysis, a truncated transcript encoding the first 3 transmembrane spanning domains was detected. (J:79483)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Drd3 Mutation:	57 strains or lines available

Original:	J:79483 Jung MY, et al., Potentiation of the D2 mutant motor phenotype in mice lacking dopamine D2 and D3 receptors. Neuroscience. 1999;91(3):911-24
All:	7 reference(s)