Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Slc9a3tm1Ges
Name:	solute carrier family 9 (sodium/hydrogen exchanger), member 3; targeted mutation 1, Gary E Shull
MGI ID:	MGI:2388341
Synonyms:	Nhe3-, NHE-3 -, Slc9a3-
Gene:	Slc9a3  Location: Chr13:74269576-74317561 bp, + strand  Genetic Position: Chr13, 40.15 cM
Alliance:	Slc9a3tm1Ges page

Germline Transmission:	Earliest citation of germline transmission: J:70885
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The gene was disrupted by insertion of a neomycin resistance cassette into exon 6. Northern blot analysis of kidney and intestinal RNA detected a truncated mutant transcript lacking codons 320-821. The residues endcoded by the deleted sequences are required for Na+/H+ exhange. (J:70885)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	9 anatomical structure(s)

List all tumor models in MMHCdb carrying Slc9a3tm1Ges

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Slc9a3 Mutation:	45 strains or lines available

Original:	J:70885 Schultheis PJ, et al., Renal and intestinal absorptive defects in mice lacking the NHE3 Na+/H+ exchanger. Nat Genet. 1998 Jul;19(3):282-5
All:	54 reference(s)