Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Hmox2tm1Poss
Name:	heme oxygenase 2; targeted mutation 1, Kenneth D Poss
MGI ID:	MGI:2388325
Synonyms:	HO-2-, HO2-, HO-2delta
Gene:	Hmox2  Location: Chr16:4544225-4584606 bp, + strand  Genetic Position: Chr16, 2.46 cM, cytoband B1
Alliance:	Hmox2tm1Poss page

Germline Transmission:	Earliest citation of germline transmission: J:29523
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Approximately 80% of the coding region was replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region included the putative membrane spanning region. Transcript was undetected in homozygous mutant mice by Northern blot analysis of brain tissue. An assay based on bilirubin production indicated complete functional ablation in homozygous mutant mice. (J:29523)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	21 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hmox2 Mutation:	25 strains or lines available

Original:	J:29523 Poss KD, et al., Hippocampal long-term potentiation is normal in heme oxygenase-2 mutant mice. Neuron. 1995 Oct;15(4):867-73
All:	53 reference(s)