Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Ddr2tm1Kln Name: discoidin domain receptor family, member 2; targeted mutation 1, Rudiger Klein MGI ID: MGI:2388155 Synonyms: DDR2- Gene: Ddr2  Location: Chr1:169799876-169938331 bp, - strand  Genetic Position: Chr1, 76.84 cM, cytoband H1-H5 Alliance: Ddr2tm1Kln page

Skull comparison of Ddr1tm1Wfv/Ddr1tm1Wfv, Ddr2tm1Kln/Ddr2tm1Kln and Ddr2tm1Kln/Ddr2+ mice Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:74580
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The exon encoding the ATP binding region of the kinase domain was replaced by a neo cassette inserted by homologous recombination. The absence of normal trancsript and normal protein was confirmed by Northern and Western blot analyses. In vitro studies showed normal proliferation of fibroblasts derived from homozygous mutant mice after infection with a retrovirus containing the wild-type cDNA. (J:74580)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ddr2 Mutation:	60 strains or lines available

Original:	J:74580 Labrador JP, et al., The collagen receptor DDR2 regulates proliferation and its elimination leads to dwarfism. EMBO Rep. 2001 May;2(5):446-52
All:	3 reference(s)