Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Pdcd1tm1Hon
Name:	programmed cell death 1; targeted mutation 1, Tasuku Honjo
MGI ID:	MGI:2386184
Synonyms:	PD-1-
Gene:	Pdcd1  Location: Chr1:93966027-93980278 bp, - strand  Genetic Position: Chr1, 47.47 cM
Alliance:	Pdcd1tm1Hon page

Germline Transmission:	Earliest citation of germline transmission: J:50688
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A region encoding both transmembrane and cytoplasmic domains was deleted by the replacement of sequence extending from within exon 3 through a portion of exon 4 with a neomycin selection cassette. Flow cytometric analysis of cultured cells derived from homozygous mutant mice showed a lack of protein expression on the cell surface. (J:50688)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

10 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 6 strains available      Cell Lines: 0 lines available
Carrying any Pdcd1 Mutation:	97 strains or lines available

Original:	J:50688 Nishimura H, et al., Immunological studies on PD-1 deficient mice: implication of PD-1 as a negative regulator for B cell responses. Int Immunol. 1998 Oct;10(10):1563-72
All:	123 reference(s)