Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Pou2af1tm1Pjln
Name:	POU domain, class 2, associating factor 1; targeted mutation 1, Peter J Nielsen
MGI ID:	MGI:2386101
Synonyms:	BOB.1/OBF.1-
Gene:	Pou2af1  Location: Chr9:51125008-51151380 bp, + strand  Genetic Position: Chr9, 27.95 cM
Alliance:	Pou2af1tm1Pjln page

Germline Transmission:	Earliest citation of germline transmission: J:37085
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 2 through 4, encompassing approximately 60% of the coding region, were replaced with a neomycin selection cassette. The deleted region encoded the amino terminal activation domain and a portion of the carboxy terminal domain. RT-PCR analysis of total spleen RNA showed an absence of transcript in homozygous mutant mice. (J:37085)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pou2af1 Mutation:	15 strains or lines available

Original:	J:37085 Nielsen PJ, et al., B lymphocytes are impaired in mice lacking the transcriptional co-activator Bob1/OCA-B/OBF1. Eur J Immunol. 1996 Dec;26(12):3214-8
All:	9 reference(s)