Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol: Krt6a/Krt6btm1Cou Name: keratin 6B; targeted mutation 1, Pierre A Coulombe MGI ID: MGI:2385808 Synonyms: K6alpha/beta null Gene: Krt6b  Location: Chr15:101584458-101588722 bp, - strand  Genetic Position: Chr15, 56.97 cM Alliance: Krt6a/Krt6btm1Cou page

Growth retardation and tongue blisters in Krt6a/Krt6btm1Cou/Krt6a/Krt6btm1Cou mice Show the 3 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:64033
Parent Cell Line:	CK35 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intergenic deletion   Mutation details: Two closely linked genes were deleted using a single targeting event. The entire Krt2-6a gene, 13 kb of intergenic sequences, and the first half of Krt2-6b exon 1 were replaced with a neomycin resistance cassette via homologous recombination. RT-PCR and Northern blot analysis of cultured keratinocytes derived from homozygous mutant animals did not detect Krt2-6a or Krt2-6b transcripts, however a probe to the neo gene yielded positive results. Western blot analysis also failed to detect either Krt2-6a or Krt2-6b protein products. (J:64033)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Krt6b Mutation:	24 strains or lines available

Original:	J:64033 Wong P, et al., Introducing a null mutation in the mouse K6alpha and K6beta genes reveals their essential structural role in the oral mucosa. J Cell Biol. 2000 Aug 21;150(4):921-8
All:	4 reference(s)