Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gasttm1Psi
Name:	gastrin; targeted mutation 1, Pomila Singh
MGI ID:	MGI:2384400
Synonyms:	GAS-KO
Gene:	Gast  Location: Chr11:100225233-100227822 bp, + strand  Genetic Position: Chr11, 63.46 cM
Alliance:	Gasttm1Psi page

Germline Transmission:	Earliest citation of germline transmission: J:77985
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: The gene was disrupted by insertion of a PGK-neo cassette into exon 2 via homologous recombination. Loss of gene expression was observed in homozygous mutant animals by RT-PCR analysis of antral mucosa samples using primers to exons 1 and 3. Protein product was undetectable in plasma from homozygous mutants. (J:77985)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gast Mutation:	18 strains or lines available

Original:	J:77985 Cobb S, et al., Deletion of functional gastrin gene markedly increases colon carcinogenesis in response to azoxymethane in mice. Gastroenterology. 2002 Aug;123(2):516-30
All:	2 reference(s)