Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Fshrtm1Saco Name: follicle stimulating hormone receptor; targeted mutation 1, Paolo Sassone-Corsi MGI ID: MGI:2384087 Synonyms: FORKO, Fshr-, FSH-R- Gene: Fshr  Location: Chr17:89292380-89508103 bp, - strand  Genetic Position: Chr17, 58.76 cM, cytoband E5 Alliance: Fshrtm1Saco page

Abnormal sperm morphology in Fshrtm1Saco/Fshrtm1Saco mice Show the 2 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:50933
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The insertion of a neomycin selection cassette deleted exon 1. Northern blot analysis of testicular and ovarian RNA showed that the deletion was sufficient for abbrogating the expression of all known isoforms. The absence of functional protein in homozygous mutant mice was confirmed by lableled ligand binding assays of testis. (J:50933)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	33 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fshr Mutation:	49 strains or lines available

Original:	J:50933 Dierich A, et al., Impairing follicle-stimulating hormone (FSH) signaling in vivo: targeted disruption of the FSH receptor leads to aberrant gametogenesis and hormonal imbalance. Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13612-7
All:	35 reference(s)