Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Fgf2tm1Bas
Name:	fibroblast growth factor 2; targeted mutation 1, Claudio Basilico
MGI ID:	MGI:2384001
Synonyms:	FGF2-
Gene:	Fgf2  Location: Chr3:37402616-37464255 bp, + strand  Genetic Position: Chr3, 18.41 cM, cytoband A2-B
Alliance:	Fgf2tm1Bas page

Germline Transmission:	Earliest citation of germline transmission: J:47664
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The insertion of a neomycin selection cassetted deleted a region of exon 1 encoding 59 amino acids and including the splicing donor site. Transcript was undetected in homozygous mutant mice via RT-PCR analysis. Western blot analysis of protein extracts obtained from various organs confirmed the absence of the 3 known isoforms produced from the endogenous locus. (J:47664)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fgf2 Mutation:	17 strains or lines available

Original:	J:47664 Ortega S, et al., Neuronal defects and delayed wound healing in mice lacking fibroblast growth factor 2. Proc Natl Acad Sci U S A. 1998 May 12;95(10):5672-7
All:	8 reference(s)