Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ehmt2tm1Yshk
Name:	euchromatic histone lysine N-methyltransferase 2; targeted mutation 1, Yoichi Shinkai
MGI ID:	MGI:2183571
Synonyms:	G9a-
Gene:	Ehmt2  Location: Chr17:35117445-35133028 bp, + strand  Genetic Position: Chr17, 18.45 cM
Alliance:	Ehmt2tm1Yshk page

Germline Transmission:	Earliest citation of germline transmission: J:77998
Parent Cell Line:	TT2 (ES Cell)
Strain of Origin:	(C57BL/6NCrlj x CBA/JNCrlj)F1

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The insertion of neomycin selection cassette deleted sequence encoding the glutamic acid stretch, adjacent cysteine-rich region, and ankyrin repeats. While low levels of truncated transcript were detected via Northern blot analysis using a probe for the SET domain, neither full-length nor truncated protein was detected by Western blot analysis. (J:77998)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

6 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ehmt2 Mutation:	55 strains or lines available

Original:	J:77998 Tachibana M, et al., G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis. Genes Dev. 2002 Jul 15;16(14):1779-91
All:	7 reference(s)