Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Frktm1Liu
Name:	fyn-related kinase; targeted mutation 1, Edison T Liu
MGI ID:	MGI:2183538
Synonyms:	FRK-, frk/rak-
Gene:	Frk  Location: Chr10:34359395-34487274 bp, + strand  Genetic Position: Chr10, 18.85 cM
Alliance:	Frktm1Liu page

Germline Transmission:	Earliest citation of germline transmission: J:77207
Parent Cell Line:	E14TG2a (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 1a and 1b were replaced with a neomycin selection cassette. The deleted region contained the 5' untranslated region, the start codon, and sequence encoding the amino terminal residues and the SH2 and SH3 domains. No transcript was detected by Northern blot anlysis of homozygous mutant mice. Western blot analysis confirmed the absence of protein. (J:77207)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Frk Mutation:	30 strains or lines available

Original:	J:77207 Chandrasekharan S, et al., Characterization of mice deficient in the Src family nonreceptor tyrosine kinase Frk/rak. Mol Cell Biol. 2002 Jul;22(14):5235-47
All:	3 reference(s)