Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tpst1tm1Klm
Name:	protein-tyrosine sulfotransferase 1; targeted mutation 1, Kevin L Moore
MGI ID:	MGI:2183366
Synonyms:	Tpst-
Gene:	Tpst1  Location: Chr5:130102167-130164570 bp, + strand  Genetic Position: Chr5, 68.53 cM, cytoband F-G1
Alliance:	Tpst1tm1Klm page

Germline Transmission:	Earliest citation of germline transmission: J:77674
Parent Cell Line:	AB2.2 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1b-m2

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 3, the first coding exon, was replaced with a neomycin selection cassette. A truncated transcript was detected in RNA derived from the testes and spleens of mutant mice. This transcript was undetected using a probe for exon 3, indicating that sequence encoding the 5' and 3' phosphate-binding domains was absent, thus translation would not result in a functional protein. (J:77674)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tpst1 Mutation:	30 strains or lines available

Original:	J:77674 Ouyang YB, et al., Reduced body weight and increased postimplantation fetal death in tyrosylprotein sulfotransferase-1-deficient mice. J Biol Chem. 2002 Jun 28;277(26):23781-7
All:	8 reference(s)