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Hrh2tm1Wtn
Targeted Allele Detail
Summary
Symbol: Hrh2tm1Wtn
Name: histamine receptor H2; targeted mutation 1, Takeshi Watanabe
MGI ID: MGI:2182949
Synonyms: H2R -, Hrh2tm1Wat
Gene: Hrh2  Location: Chr13:54346148-54390199 bp, + strand  Genetic Position: Chr13, 28.4 cM
Alliance: Hrh2tm1Wtn page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:62871
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin selection cassette replaced most of the coding region of the gene including the translation initiation codon. RT-PCR analysis confirmed that no detectable transcript was expressed from this allele in stomach or brain of homozygous mice. (J:62871)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Hrh2 Mutation:  26 strains or lines available
References
Original:  J:62871 Kobayashi T, et al., Abnormal functional and morphological regulation of the gastric mucosa in histamine H2 receptor-deficient mice. J Clin Invest. 2000 Jun;105(12):1741-9
All:  18 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory