Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Hivep2tm1Sis
Name:	human immunodeficiency virus type I enhancer binding protein 2; targeted mutation 1, Shunsuke Ishii
MGI ID:	MGI:2182914
Synonyms:	Shn-2-
Gene:	Hivep2  Location: Chr10:13841819-14027118 bp, + strand  Genetic Position: Chr10, 5.14 cM, cytoband A2
Alliance:	Hivep2tm1Sis page

Germline Transmission:	Earliest citation of germline transmission: J:72249
Parent Cell Line:	TT2 (ES Cell)
Strain of Origin:	(C57BL/6NCrlj x CBA/JNCrlj)F1

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A 0.9 kb region of the gene encoding amino acids 1-1713 and containing the N-terminal zinc finger cluster was replaced with a neomycin resistance cassette via homologous recombination. Western blot analysis of T cells from homozygous mutant animals using monoclonal antibodies directed against amino acids 2287-2500 did not detect protein expression. (J:72249)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	8 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Hivep2 Mutation:	108 strains or lines available

Original:	J:72249 Takagi T, et al., Murine Schnurri-2 is required for positive selection of thymocytes. Nat Immunol. 2001 Nov;2(11):1048-53
All:	14 reference(s)