Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Acsl4tm1Tty
Name:	acyl-CoA synthetase long-chain family member 4; targeted mutation 1, Tokuo T Yamamoto
MGI ID:	MGI:2182854
Synonyms:	ACS4-
Gene:	Acsl4  Location: ChrX:141100989-141173531 bp, - strand  Genetic Position: ChrX, 63.12 cM
Alliance:	Acsl4tm1Tty page

Germline Transmission:	Earliest citation of germline transmission: J:70023
Parent Cell Line:	TT2 (ES Cell)
Strain of Origin:	(C57BL/6NCrlj x CBA/JNCrlj)F1

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A neomycin selection cassette was inserted into exon 2, which is the first coding exon. Immunoblotting of hemizygous mutant ES cells showed an absence of protein. (J:70023)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Acsl4 Mutation:	13 strains or lines available

Original:	J:70023 Cho YY, et al., Abnormal uterus with polycysts, accumulation of uterine prostaglandins, and reduced fertility in mice heterozygous for acyl-CoA synthetase 4 deficiency. Biochem Biophys Res Commun. 2001 Jun 22;284(4):993-7
All:	1 reference(s)