Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol: Nppctm1Yog Name: natriuretic peptide type C; targeted mutation 1, Yoshihiro Ogawa MGI ID: MGI:2182456 Synonyms: Nppc- Gene: Nppc  Location: Chr1:86594015-86598295 bp, - strand  Genetic Position: Chr1, 43.98 cM Alliance: Nppctm1Yog page

Dwarfism in Nppctm1Yog/Nppctm1Yog mice Show the 2 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:75620
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129/Sv

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 1 and 2, which contain the entire coding sequence, were replaced with a neomycin resistance gene via homologous recombination. RNase protection assays demonstrated the absence of gene expression in various tissues from homozygous mutant animals. (J:75620)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

7 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nppc Mutation:	12 strains or lines available

Original:	J:75620 Chusho H, et al., Dwarfism and early death in mice lacking C-type natriuretic peptide. Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):4016-21
All:	4 reference(s)