Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ncantm1Ref
Name:	neurocan; targeted mutation 1, Reinhard Fassler
MGI ID:	MGI:2182148
Synonyms:	NCIg
Gene:	Ncan  Location: Chr8:70545735-70573494 bp, - strand  Genetic Position: Chr8, 34.15 cM
Alliance:	Ncantm1Ref page

Germline Transmission:	Earliest citation of germline transmission: J:70858
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A neomycin selection cassette was inserted into exon 3, which encodes the immunoglobulin-like domain. Transcript was detected in homozygous mutant mice via Norhtern blot analysis. RT-PCR revealed that the detected signal was that of an aberrant transcript from which exon 3 had been excised. Western blot analysis showed an absence of protein. (J:70858)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ncan Mutation:	46 strains or lines available

Original:	J:70858 Zhou XH, et al., Neurocan is dispensable for brain development. Mol Cell Biol. 2001 Sep;21(17):5970-8
All:	2 reference(s)