Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Rhotm1Phm
Name:	rhodopsin; targeted mutation 1, Peter Humphries
MGI ID:	MGI:2181812
Synonyms:	R-, Rho-
Gene:	Rho  Location: Chr6:115908709-115916997 bp, + strand  Genetic Position: Chr6, 53.72 cM
Alliance:	Rhotm1Phm page

Germline Transmission:	Earliest citation of germline transmission: J:38098
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A neomycin cassette under the control of a polymerase II promoter was inserted at codon 135 in exon 2. RT-PCR analysis of total RNA derived from ocular tissue showed an absence of transcript in homozygous mutant mice. A lack of encoded protein was determined in homozygous mutant mice via immunocytochemical staining of retinal sections. (J:38098)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Rho Mutation:	48 strains or lines available

Original:	J:38098 Humphries MM, et al., Retinopathy induced in mice by targeted disruption of the rhodopsin gene [see comments]. Nat Genet. 1997 Feb;15(2):216-9
All:	75 reference(s)