Cacnb1tm1Rgg
Targeted Allele Detail
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| Symbol: |
Cacnb1tm1Rgg |
| Name: |
calcium channel, voltage-dependent, beta 1 subunit; targeted mutation 1, Ronald G Gregg |
| MGI ID: |
MGI:2181804 |
| Synonyms: |
cchb1tm1, cchbl- |
| Gene: |
Cacnb1 Location: Chr11:97892339-97913860 bp, - strand Genetic Position: Chr11, 61.5 cM
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| Alliance: |
Cacnb1tm1Rgg page
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Muscle mass reduction and disorganization of myofibrils in Cacnb1tm1Rgg/Cacnb1tm1Rgg mice
Show the 1 phenotype image(s) involving this allele.
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| Germline Transmission: |
Earliest citation of germline transmission:
J:37052
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| Parent Cell Line: |
AB1 (ES Cell)
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| Strain of Origin: |
129S7/SvEvBrd-Hprt1+
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A neomycin selection cassette replaced exon 6, which is common to all isoforms, and exons 7a and 7b, which are specific to muscle and brain isoforms, respectively. Protein was undetected by immunofluorescence analysis of homozygous mutant myotubes.
(J:37052)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Cacnb1 Mutation: |
26 strains or lines available
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| Original: |
J:37052 Gregg RG, et al., Absence of the beta subunit (cchb1) of the skeletal muscle dihydropyridine receptor alters expression of the alpha 1 subunit and eliminates excitation-contraction coupling. Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):13961-6 |
| All: |
6 reference(s) |
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Analysis Tools
