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Igf2rtm1Stw
Targeted Allele Detail
Summary
Symbol: Igf2rtm1Stw
Name: insulin-like growth factor 2 receptor; targeted mutation 1, Colin L Stewart
MGI ID: MGI:2181634
Gene: Igf2r  Location: Chr17:12901293-12988551 bp, - strand  Genetic Position: Chr17, 8.64 cM, cytoband A-C
Alliance: Igf2rtm1Stw page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:22124
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: The gene was disrupted by replacement of exons 13-18 with a PGK-neo cassette via homologous recombination. (J:22124)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 67 assay results
In Structures Affected by this Mutation: 12 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Igf2r Mutation:  98 strains or lines available
Notes
This gene is paternally imprinted and only expressed when maternally inherited. When this allele is inherited maternally mice are equivalent to homozygous knock-out mice and when this allele is inherited paternally mice are equivalent to homozygous wild-type mice.
References
Original:  J:22124 Lau MM, et al., Loss of the imprinted IGF2/cation-independent mannose 6-phosphate receptor results in fetal overgrowth and perinatal lethality. Genes Dev. 1994 Dec 15;8(24):2953-63
All:  4 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory