Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol: Bmpr1atm2.2Bhr Name: bone morphogenetic protein receptor, type 1A; targeted mutation 2.2, Richard R Behringer MGI ID: MGI:2181295 Synonyms: Bmpr1a-, deltae2, deltaexon2 Gene: Bmpr1a  Location: Chr14:34133018-34225335 bp, - strand  Genetic Position: Chr14, 20.81 cM Alliance: Bmpr1atm2.2Bhr page

Joint defects in Bmpr1atm2.1Bhr/Bmpr1atm2.2Bhr Tg(Gdf5-cre,-ALPP)1Kng/0 mice Show the 2 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:75074
Parent Cell Line:	AB1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1+

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: Homologous recombination introduced a floxed neomycin resistance cassette into intron 2, and a single loxP site into intron 1. Cre-mediated recombination in vivo under the control of a CMV promoter excised the neo cassette and exon 2, which encodes roughly a third of the extracellular domain of the receptor within the ligand-binding domain. (J:75074)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

11 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bmpr1a Mutation:	89 strains or lines available

Original:	J:75074 Mishina Y, et al., Generation of Bmpr/Alk3 conditional knockout mice. Genesis. 2002 Feb;32(2):69-72
All:	14 reference(s)