Serpinf2tm1Hrl
Targeted Allele Detail
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| Symbol: |
Serpinf2tm1Hrl |
| Name: |
serine (or cysteine) peptidase inhibitor, clade F, member 2; targeted mutation 1, H Roger Lijnen |
| MGI ID: |
MGI:2181226 |
| Synonyms: |
alpha-2-AP-, alpha2-AP- |
| Gene: |
Serpinf2 Location: Chr11:75322562-75330327 bp, - strand Genetic Position: Chr11, 45.89 cM
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| Alliance: |
Serpinf2tm1Hrl page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:54047
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| Parent Cell Line: |
RW-4 (ES Cell)
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| Strain of Origin: |
129X1/SvJ
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A neomycin cassette replaced the entire coding region (exon 2 through the stop codon in exon 10). RT-PCR analaysis of kidney and liver tissue showed an absence of transcript in homozygous mutant mice. Western blot analyses of unactivated and activated plasma confirmed a lack of encoded protein in homozygous mice. Complex formation was undetectable by blotting analysis of plasma incubated with purified plasmin.
(J:43244, J:54047)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Serpinf2 Mutation: |
23 strains or lines available
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| Original: |
J:54047 Lijnen HR, et al., Alpha2-antiplasmin gene deficiency in mice is associated with enhanced fibrinolytic potential without overt bleeding. Blood. 1999 Apr 1;93(7):2274-81 |
| All: |
15 reference(s) |
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Analysis Tools
