Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Seletm1Roml
Name:	selectin, endothelial cell; targeted mutation 1, Mark A Labow
MGI ID:	MGI:2180868
Synonyms:	E-selectin (-)
Gene:	Sele  Location: Chr1:163875773-163885246 bp, + strand  Genetic Position: Chr1, 71.35 cM
Alliance:	Seletm1Roml page

Germline Transmission:	Earliest citation of germline transmission: J:22062
Parent Cell Line:	W9.5/W95 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: The gene was disrupted by insertion of a neomycin resistance cassette into exon 1 after amino acid 162 of the LEC domain resulting in disruption of the protein's carbohydrate-binding domain. Northern blot analysis of lung from homozygous mutant animals detected several alternatively spliced mutant transcripts. Western blot, immunoprecipitation, and immunohistochemistry analyses were unable to detect gene expression in hearts from homozygous mutant animals. (J:22062)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sele Mutation:	51 strains or lines available

Original:	J:22062 Labow MA, et al., Characterization of E-selectin-deficient mice: demonstration of overlapping function of the endothelial selectins. Immunity. 1994 Nov;1(8):709-20
All:	7 reference(s)