Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | Notes | References

Symbol:	Cebpbtm1Kish
Name:	CCAAT/enhancer binding protein beta; targeted mutation 1, Tadamitsu Kishimoto
MGI ID:	MGI:2180848
Synonyms:	NF-IL6(-)
Gene:	Cebpb  Location: Chr2:167530835-167532338 bp, + strand  Genetic Position: Chr2, 87.58 cM
Alliance:	Cebpbtm1Kish page

Germline Transmission:	Earliest citation of germline transmission: J:77003
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin selection cassette replaced a 0.5kb genomic region encoding the basic and the leucine-zipper domains and the 3' untranslated region sequences. Northern blot analysis confirmed a lack of transcript in homozygous mutant mice. (J:77003)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	37 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 8 strains available      Cell Lines: 0 lines available
Carrying any Cebpb Mutation:	23 strains or lines available

Original:	J:77003 Tanaka T, et al., Targeted disruption of the NF-IL6 gene discloses its essential role in bacteria killing and tumor cytotoxicity by macrophages. Cell. 1995 Jan 27;80(2):353-61
All:	16 reference(s)