Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ccl5tm1Hso
Name:	C-C motif chemokine ligand 5; targeted mutation 1, Hiroshi Sato
MGI ID:	MGI:2180195
Synonyms:	CCL5-KO, RANTES-
Gene:	Ccl5  Location: Chr11:83416604-83421344 bp, - strand  Genetic Position: Chr11, 50.66 cM
Alliance:	Ccl5tm1Hso page

Germline Transmission:	Earliest citation of germline transmission: J:75842
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A 333 bp region of the gene containing the promoter, transcription and translation initiation sites, and part of exon 1 was replaced with a PGK-hygro cassette via homologous recombination. Northern blot analysis confirmed the absence of gene expression in homozygous mutant mice. (J:75842)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ccl5 Mutation:	10 strains or lines available

Original:	J:75842 Makino Y, et al., Impaired T cell function in RANTES-deficient mice. Clin Immunol. 2002 Mar;102(3):302-9
All:	42 reference(s)