Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Scn10atm1Jwo
Name:	sodium channel, voltage-gated, type X, alpha; targeted mutation 1, John N Wood
MGI ID:	MGI:2180183
Synonyms:	Nav1.8-, Scn10atm1Jnw, SNS-
Gene:	Scn10a  Location: Chr9:119437522-119548388 bp, - strand  Genetic Position: Chr9, 71.33 cM, cytoband distal
Alliance:	Scn10atm1Jwo page

Germline Transmission:	Earliest citation of germline transmission: J:76456
Parent Cell Line:	E14TG2a (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Part of exon 4 and all of exon 5, which encodes the S4 voltage sensor of domain I, were replaced with a PGK-neo cassette via homologous recombination. The PGK-neo cassette introduces stop codons in all 3 reading frames. RT-PCR analysis detected weak expression of mutant transcripts in homozygous mutant animals. (J:76456)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Scn10a Mutation:	102 strains or lines available

Original:	J:76456 Akopian AN, et al., The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways. Nat Neurosci. 1999 Jun;2(6):541-8
All:	28 reference(s)