Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Adora1tm1Bbf
Name:	adenosine A1 receptor; targeted mutation 1, Bertil B Fredholm
MGI ID:	MGI:2180136
Synonyms:	A1AR-, A1-KO, A1R-
Gene:	Adora1  Location: Chr1:134126963-134163169 bp, - strand  Genetic Position: Chr1, 58.15 cM, cytoband E4
Alliance:	Adora1tm1Bbf page

Germline Transmission:	Earliest citation of germline transmission: J:70664
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A PGK-neo cassette replaced most of the coding region and a portion of the of the 3' flanking region of the targeted exon. An absence of the normal protein was observed using in situ hybridization and autoradiographic analysis using a labeled ligand, DPCPX. (J:70664)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Adora1 Mutation:	22 strains or lines available

Original:	J:70664 Johansson B, et al., Hyperalgesia, anxiety, and decreased hypoxic neuroprotection in mice lacking the adenosine A1 receptor. Proc Natl Acad Sci U S A. 2001 Jul 31;98(16):9407-12
All:	56 reference(s)