Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Krt18tm1Tmm
Name:	keratin 18; targeted mutation 1, Thomas M Magin
MGI ID:	MGI:2178045
Synonyms:	K18-, K18 null
Gene:	Krt18  Location: Chr15:101936651-101940461 bp, + strand  Genetic Position: Chr15, 57.22 cM, cytoband F3
Alliance:	Krt18tm1Tmm page

Germline Transmission:	Earliest citation of germline transmission: J:46610
Parent Cell Line:	HM-1 (ES Cell)
Strain of Origin:	129P2/OlaHsd-Hprt1b-m3

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion     An HPRT minigene replaced most of exon 1, intron 1 and exon 2. (J:46610)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Krt18 Mutation:	28 strains or lines available

Original:	J:46610 Magin TM, et al., Lessons from keratin 18 knockout mice: formation of novel keratin filaments, secondary loss of keratin 7 and accumulation of liver-specific keratin 8-positive aggregates. J Cell Biol. 1998 Mar 23;140(6):1441-51
All:	15 reference(s)