Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Gad1tm1Mrc Name: glutamate decarboxylase 1; targeted mutation 1, Mario R Capecchi MGI ID: MGI:2177566 Synonyms: GAD67 - Gene: Gad1  Location: Chr2:70391644-70432358 bp, + strand  Genetic Position: Chr2, 41.63 cM, cytoband D Alliance: Gad1tm1Mrc page

Cleft palate phenotype in Gad1tm1Mrc/Gad1tm1Mrc mice Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:43954
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A neomycin selection cassette was inserted into the first coding exon. RNase protection assays on RNA derived from brain of homozygous mice confirmed that no detectable transcript is produced from this allele. (J:43954)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	10 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gad1 Mutation:	64 strains or lines available

Original:	J:43954 Condie BG, et al., Cleft palate in mice with a targeted mutation in the gamma-aminobutyric acid-producing enzyme glutamic acid decarboxylase 67. Proc Natl Acad Sci U S A. 1997 Oct 14;94(21):11451-5
All:	3 reference(s)