Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol: Mapk9tm1Flv Name: mitogen-activated protein kinase 9; targeted mutation 1, Richard Flavell MGI ID: MGI:2176243 Synonyms: Jnk2-, Jnk2 KO Gene: Mapk9  Location: Chr11:49737578-49777248 bp, + strand  Genetic Position: Chr11, 29.96 cM, cytoband B1.2 Alliance: Mapk9tm1Flv page

Abnormal epidermis of adult Mapk8tm1Flv/Mapk8tm1Flv and Mapk9tm1Flv/Mapk9tm1Flv mice Show the 4 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:50628
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin selection cassette replaced a genomic fragment containing three coding exons containing sequences required for protein kinase activity. RT-PCR analysis on RNA derived from thymus of homozygous mice confirmed that no detectable transcript is produced from this allele. Western blot analysis on brain, thymocyte and T cells derived from homozygous mice confirmed that no protein was expressed from this allele. (J:50628)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	86 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

List all tumor models in MMHCdb carrying Mapk9tm1Flv

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Mapk9 Mutation:	33 strains or lines available

Original:	J:50628 Yang DD, et al., Differentiation of CD4+ T cells to Th1 cells requires MAP kinase JNK2. Immunity. 1998 Oct;9(4):575-85
All:	121 reference(s)