Ptprftm1Wjh
Targeted Allele Detail
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Symbol: |
Ptprftm1Wjh |
Name: |
protein tyrosine phosphatase receptor type F; targeted mutation 1, Wiljan JAJ Hendriks |
MGI ID: |
MGI:2158762 |
Synonyms: |
LAR-, LARdeltaP |
Gene: |
Ptprf Location: Chr4:118065410-118148602 bp, - strand Genetic Position: Chr4, 54.47 cM, cytoband C6-D1
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Alliance: |
Ptprftm1Wjh page
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Craniofacial anomalies in Ptprftm1Wjh/Ptprftm1Wjh Ptprstm1Mtr/Ptprstm1Mtr double-mutant embryos
Show the 5 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:42273
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Parent Cell Line: |
E14 (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A neomycin resistance cassette replaced the exons encoding the cytoplasmic tyrosine phosphatase domains. Northern blot analyses detected truncated but not wild-type transcripts in several tissues from homozygous mutant 3 month old male mice. Truncated protein was also detected on the surface of homozgyote thymocytes with reduced expression compared to endogenous protein.
(J:42273, J:119456)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Ptprf Mutation: |
100 strains or lines available
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Original: |
J:42273 Schaapveld RQ, et al., Impaired mammary gland development and function in mice lacking LAR receptor-like tyrosine phosphatase activity. Dev Biol. 1997 Aug 1;188(1):134-46 |
All: |
10 reference(s) |
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