Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Kifc2tm1Gsn
Name:	kinesin family member C2; targeted mutation 1, Lawrence SB Goldstein
MGI ID:	MGI:2158351
Gene:	Kifc2  Location: Chr15:76544058-76552396 bp, + strand  Genetic Position: Chr15, 36.23 cM, cytoband D-E
Alliance:	Kifc2tm1Gsn page

Germline Transmission:	Earliest citation of germline transmission: J:68003
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A 4.0 kb genomic fragment containing the coding sequences for amino acids 31 to 560 was replaced with a neomycin selection cassette. These sequences correspond to the tail and alpha coiled coil domains and half of the motor domain. Northern blot analysis on RNA derived from brain of homozygous mice confirmed that no detectable transcript was produced from this allele. In addition, western blot analysis demonstrated that no encoded protein was detectable in brain lysates derived from homozygous mice. (J:68003)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Kifc2 Mutation:	25 strains or lines available

Original:	J:68003 Yang Z, et al., Functional analysis of mouse c-terminal kinesin motor kifc2. Mol Cell Biol. 2001 Apr;21(7):2463-6
All:	2 reference(s)