Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Il1rntm1Dih
Name:	interleukin 1 receptor antagonist; targeted mutation 1, David Hirsh
MGI ID:	MGI:2157398
Synonyms:	IL-1ra-, rako
Gene:	Il1rn  Location: Chr2:24226872-24241503 bp, + strand  Genetic Position: Chr2, 16.36 cM
Alliance:	Il1rntm1Dih page

Germline Transmission:	Earliest citation of germline transmission: J:36387
Parent Cell Line:	CCE/EK.CCE (ES Cell)
Strain of Origin:	129S/SvEv-Gpi1c

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: Insertion of a neomycin resistance cassette into exon III disrupted the sequence encoding the secreted protein. Northern blot analysis of lung tissue collected after LPS injection did not detect transcript in homozygous mutant mice. (J:36387)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Il1rn Mutation:	23 strains or lines available

Original:	J:36387 Hirsch E, et al., Functions of interleukin 1 receptor antagonist in gene knockout and overproducing mice. Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):11008-13
All:	22 reference(s)