Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Rasgrf1tm1Kln
Name:	RAS protein-specific guanine nucleotide-releasing factor 1; targeted mutation 1, Rudiger Klein
MGI ID:	MGI:2157015
Synonyms:	Ras-GRF -, Ras-GRF1-KO
Gene:	Rasgrf1  Location: Chr9:89791961-89909030 bp, + strand  Genetic Position: Chr9, 47.31 cM
Alliance:	Rasgrf1tm1Kln page

Germline Transmission:	Earliest citation of germline transmission: J:73879
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A genomic fragment containing exons 3-5 was replaced with a neomycin selection cassette. This region encodes the exchange-factor catalytic domain. Western blot analysis on brain extracts of homozygous mice indicated that no detectable protein was produced from this allele. (J:73879)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Rasgrf1 Mutation:	65 strains or lines available

Original:	J:73879 Brambilla R, et al., A role for the Ras signalling pathway in synaptic transmission and long-term memory. Nature. 1997 Nov 20;390(6657):281-6
All:	10 reference(s)