Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Smad1tm1Rob
Name:	SMAD family member 1; targeted mutation 1, Elizabeth J Robertson
MGI ID:	MGI:2155483
Synonyms:	Smad1Robm1
Gene:	Smad1  Location: Chr8:80065024-80126057 bp, - strand  Genetic Position: Chr8, 37.56 cM
Alliance:	Smad1tm1Rob page

Germline Transmission:	Earliest citation of germline transmission: J:71998
Parent Cell Line:	CCE/EK.CCE (ES Cell)
Strain of Origin:	129S/SvEv-Gpi1c

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A PGK-neomycin resistance cassette replaced most of the first coding exon and 30bp of 3' flanking sequence, including the initiation codon and sequences encoding most of the MH1 domain. Northern analysis of 9.5dpc homozygous embryos detected a shorter transcript, but not the wild-type transcript, using a probe for the 3' UTR. Western blot analysis using an antibody that recognizes the MH2 domain did not detect intact or truncated protein in 9.5dpc homozygous embryos. (J:71998)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	28 assay results
In Structures Affected by this Mutation:	10 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Smad1 Mutation:	32 strains or lines available

Original:	J:71998 Tremblay KD, et al., Mouse embryos lacking Smad1 signals display defects in extra-embryonic tissues and germ cell formation. Development. 2001 Sep;128(18):3609-21
All:	3 reference(s)