Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Pth1rtm1Hmk
Name:	parathyroid hormone 1 receptor; targeted mutation 1, Henry M Kronenberg
MGI ID:	MGI:2154519
Synonyms:	PTHrP receptor-
Gene:	Pth1r  Location: Chr9:110551153-110576213 bp, - strand  Genetic Position: Chr9, 60.56 cM, cytoband F
Alliance:	Pth1rtm1Hmk page

Germline Transmission:	Earliest citation of germline transmission: J:34604
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced exons E2 through T, which encode most of the receptor. In situ hybridization using a probe transcribed from rat receptor cDNA detected strong signal in four, and no signal in one, of five E9.5 embryos from heterozygous matings. (J:34604)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	15 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pth1r Mutation:	28 strains or lines available

Original:	J:34604 Lanske B, et al., PTH/PTHrP receptor in early development and Indian hedgehog-regulated bone growth [see comments]. Science. 1996 Aug 2;273(5275):663-6
All:	19 reference(s)