Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Abl1tm1Mlg
Name:	c-abl oncogene 1, non-receptor tyrosine kinase; targeted mutation 1, Richard C Mulligan
MGI ID:	MGI:2153718
Synonyms:	abl-, Abl2, ablm2, c-Abl-, c-abl2
Gene:	Abl1  Location: Chr2:31578388-31694239 bp, + strand  Genetic Position: Chr2, 21.86 cM, cytoband B
Alliance:	Abl1tm1Mlg page

Germline Transmission:	Earliest citation of germline transmission: J:72875
Parent Cell Line:	CCE/EK.CCE (ES Cell)
Strain of Origin:	129S/SvEv-Gpi1c

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A genomic fragment containing exon 5 and part of exon 6 was replaced by a neomycin resistance cassette. These sequences encode the N-terminal part of the tyrosine kinase domain, including the nucleotide and ATP binding sites. (J:72875)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	12 assay results
In Structures Affected by this Mutation:	12 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Abl1 Mutation:	92 strains or lines available

Original:	J:72875 Tybulewicz VL, et al., Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene. Cell. 1991 Jun 28;65(7):1153-63
All:	29 reference(s)