Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Insrtm1Jja
Name:	insulin receptor; targeted mutation 1, Jacques Jami
MGI ID:	MGI:2149629
Synonyms:	Insr-, IR-
Gene:	Insr  Location: Chr8:3200922-3329649 bp, - strand  Genetic Position: Chr8, 1.82 cM
Alliance:	Insrtm1Jja page

Germline Transmission:	Earliest citation of germline transmission: J:32538
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced 3.6 kb of sequence, including exon 2. Western blot analysis did not detect the protein in liver extracts from homozygous mutant mice. (J:32538)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Insr Mutation:	94 strains or lines available

Original:	J:32538 Joshi RL, et al., Targeted disruption of the insulin receptor gene in the mouse results in neonatal lethality. EMBO J. 1996 Apr 1;15(7):1542-7
All:	4 reference(s)