Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cdh5tm2Pec
Name:	cadherin 5; targeted mutation 2, Peter Carmeliet
MGI ID:	MGI:2148549
Synonyms:	VE-cadherin-, VECnull
Gene:	Cdh5  Location: Chr8:104828257-104871143 bp, + strand  Genetic Position: Chr8, 53.04 cM
Alliance:	Cdh5tm2Pec page

Germline Transmission:	Earliest citation of germline transmission: J:56509
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin selection cassette replaced a genomic fragment containing exons 3-7. Western blot analysis on endothelial cells derived from homozygous mice confirmed that no detectable protein was made. (J:56509)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cdh5 Mutation:	53 strains or lines available

Original:	J:56509 Carmeliet P, et al., Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis. Cell. 1999 Jul 23;98(2):147-57
All:	6 reference(s)