Lamb2<tm1Jrs> Targeted Allele Detail MGI Mouse (MGI:2138070)

Lamb2^tm1Jrs
Targeted Allele Detail

Summary

Symbol:	Lamb2^tm1Jrs
Name:	laminin, beta 2; targeted mutation 1, Joshua R Sanes
MGI ID:	MGI:2138070
Synonyms:	beta2, Lamb2-
Gene:	Lamb2 Location: Chr9:108357080-108367729 bp, + strand Genetic Position: Chr9, 59.4 cM, cytoband F1
Alliance:	Lamb2^tm1Jrs page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:23783
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutation:		Insertion
		Insertion of a neomycin cassette into the second exon of the gene. (J:23783)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Lamb2 Mutation:	76 strains or lines available

Notes

Phenotypic Similarity to Human Syndrome: human congenital or idiopathic nephritic syndromes such as minimal change nephrotic syndrome (MCNS) and glomerulonephrosis (J:27732).

References

Original:	J:23783 Noakes PG, et al., Aberrant differentiation of neuromuscular junctions in mice lacking s-laminin/laminin beta 2. Nature. 1995 Mar 16;374(6519):258-62
All:	29 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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