Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Pdgfrbtm1Sor
Name:	platelet derived growth factor receptor, beta polypeptide; targeted mutation 1, Philippe Soriano
MGI ID:	MGI:2135508
Synonyms:	PDGFR-beta-, PDGFRbeta null
Gene:	Pdgfrb  Location: Chr18:61178222-61218133 bp, + strand  Genetic Position: Chr18, 34.41 cM
Alliance:	Pdgfrbtm1Sor page

Germline Transmission:	Earliest citation of germline transmission: J:20016
Parent Cell Line:	AB1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced 1.8 kb of genomic sequence, which encodes part of the signal peptide and the second immunoglobulin domain. Northern blot analysis detected a shorter transcript in homozygous mutant mice that was presumed to be due to exon skipping. Western blot analysis of total protein failed to detect any encoded protein in homozygous mice. (J:20016)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	2 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	10 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pdgfrb Mutation:	84 strains or lines available

Original:	J:20016 Soriano P, Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant mice. Genes Dev. 1994 Aug 15;8(16):1888-96
All:	32 reference(s)