Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Soat1tm1Ishi Name: sterol O-acyltransferase 1; targeted mutation 1, Shun Ishibashi MGI ID: MGI:1934032 Synonyms: ACAT-1 Gene: Soat1  Location: Chr1:156255678-156301898 bp, - strand  Genetic Position: Chr1, 67.71 cM Alliance: Soat1tm1Ishi page

Narrow eye fissures and atrophic meibomian glands in Soat1tm1Ishi/Soat1tm1Ishi mice Show the 3 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:63468
Parent Cell Line:	JH1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced 4 kb of sequence encoding the first transmembrane domain and a conserved serine. Northern blot analyses of homozygous mutant mice did not detect any transcripts in macrophages, adrenal glands, ovaries and testes. Western blot analyses of macrophages, adrenal glands, ovaries, and testes did not detect the protein in homozygous mutant mice. (J:63468)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Soat1 Mutation:	40 strains or lines available

Original:	J:63468 Yagyu H, et al., Absence of ACAT-1 attenuates atherosclerosis but causes dry eye and cutaneous xanthomatosis in mice with congenital hyperlipidemia. J Biol Chem. 2000 Jul 14;275(28):21324-30
All:	2 reference(s)