Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Zp2tm1Dean
Name:	zona pellucida glycoprotein 2; targeted mutation 1, Jurrien Dean
MGI ID:	MGI:1932591
Synonyms:	Zp2tm, Zp2tm1Nih, Zp2tm2Nih
Gene:	Zp2  Location: Chr7:119725995-119744514 bp, - strand  Genetic Position: Chr7, 64.38 cM
Alliance:	Zp2tm1Dean page

Germline Transmission:	Earliest citation of germline transmission: J:67817
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Part of exon 1 and exon 2 were replaced by a neomycin cassette. Absence of the protein was confirmed by immunohistochemistry on ovarian sections of mutant female mice. (J:67817)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 5 strains available      Cell Lines: 0 lines available
Carrying any Zp2 Mutation:	49 strains or lines available

Original:	J:67817 Rankin TL, et al., Defective zonae pellucidae in Zp2-null mice disrupt folliculogenesis, fertility and development. Development. 2001 Apr;128(7):1119-26
All:	6 reference(s)