Summary | Mutation origin | Mutation description | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol: F9tm1Ver Name: coagulation factor IX; targeted mutation 1, Inder M Verma MGI ID: MGI:1932265 Synonyms: FIX (-) Gene: F9  Location: ChrX:59044824-59076119 bp, + strand  Genetic Position: ChrX, 33.5 cM, cytoband A6-A7 Alliance: F9tm1Ver page

Bleeding disorder of F9tm1Ver/F9tm1Ver mice Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:43590
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Replacement of the last exon, encoding a large portion of the catalytic domain, with a neomycin cassette. mRNA was not detected in mutant mouse liver as assayed by Northern blot analysis, and no protein could be detected by Western blot analysis of plasma. (J:43590)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any F9 Mutation:	8 strains or lines available

Original:	J:43590 Wang L, et al., A factor IX-deficient mouse model for hemophilia B gene therapy. Proc Natl Acad Sci U S A. 1997 Oct 14;94(21):11563-6
All:	7 reference(s)