Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Hoxa1tm2Ipc
Name:	homeobox A1; targeted mutation 2, Pierre Chambon
MGI ID:	MGI:1931847
Synonyms:	Hoxa13'RARE, Hoxa1deltaRARE-(L)
Gene:	Hoxa1  Location: Chr6:52132573-52135299 bp, - strand  Genetic Position: Chr6, 25.4 cM
Alliance:	Hoxa1tm2Ipc page

Germline Transmission:	Earliest citation of germline transmission: J:38388
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: 18 bps of the 3'RARE were replaced by a Sal1 restriction enzyme site. A lox-P flanked neomycin cassette was inserted into the Sal1 site and was later removed via Cre-mediated recombination in the final allele. (J:38388) Inheritance:    Recessive

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

53 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hoxa1 Mutation:	14 strains or lines available

Original:	J:38388 Dupe V, et al., In vivo functional analysis of the Hoxa-1 3' retinoic acid response element (3'RARE). Development. 1997 Jan;124(2):399-410
All:	3 reference(s)