Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	B2mtm1Jae
Name:	beta-2 microglobulin; targeted mutation 1, Rudolf Jaenisch
MGI ID:	MGI:1927183
Synonyms:	B2M-, beta2M-, beta2mnull, MHC classI-
Gene:	B2m  Location: Chr2:121978168-121983563 bp, + strand  Genetic Position: Chr2, 60.55 cM, cytoband F1-F3
Alliance:	B2mtm1Jae page

Germline Transmission:	Earliest citation of germline transmission: J:65613
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion     A neomycin resistance cassette was inserted into the second exon. (J:65613, J:80910) Inheritance:    Recessive

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 8 strains available      Cell Lines: 0 lines available
Carrying any B2m Mutation:	122 strains or lines available

Original:	J:65613 Zijlstra M, et al., Germ-line transmission of a disrupted beta 2-microglobulin gene produced by homologous recombination in embryonic stem cells. Nature. 1989 Nov 23;342(6248):435-8
All:	221 reference(s)