Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Lbptm1Jack
Name:	lipopolysaccharide binding protein; targeted mutation 1, Robert S Jack
MGI ID:	MGI:1857976
Synonyms:	LBP -, Lbptm1Csc
Gene:	Lbp  Location: Chr2:158148413-158174772 bp, + strand  Genetic Position: Chr2, 78.72 cM
Alliance:	Lbptm1Jack page

Germline Transmission:	Earliest citation of germline transmission: J:43514
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A neomycin resistance gene was inserted into an exon encoding alanine 43 to serine 55. No LBP activity was detectable by ELISA assay in serum derived from homozygous mice. (J:43514)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Lbp Mutation:	28 strains or lines available

Original:	J:43514 Jack RS, et al., Lipopolysaccharide-binding protein is required to combat a murine gram-negative bacterial infection. Nature. 1997 Oct 16;389(6652):742-5
All:	6 reference(s)